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Preprint at (2020)

Alternatively, assessment of excessively high drug levels may be helpful in settings for which there is a concern where patients are at risk of supratherapeutic DOAC concentrations due to reduced drug clearance such as those with concurrent renal or liver impairment, low body weight, or suspected drug-drug interactions9

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They reflect the body's struggle to produce enough healthy red blood cells to ferry oxygen around efficiently

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In patients requiring regular transfusions, excess iron accumulates in the body, depositing in vital organs such as the heart, liver, and endocrine glands, eventually leading to organ dysfunction if not carefully managed [9][13]